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In GLP-1R -/- mice, lack of GLP-1R expression in adipocytes caused a reduction in adipogenesis, through the induction of apoptosis in pre-adipocytes by inhibiting ERK, PKC, and AKT signaling pathways (50) ( Figure 2 )

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While it is too early to say that GLP-1s prevent dementia, early results point toward meaningful cognitive protection

While these drugs hold incredible promise, off-label use is a gray areaand one that comes with both potential benefits and risks