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Subsequently, the cells were treated with Mn@mHSA, P-Mn@mHSA and P-Mn/TI@mHSA (at the concentration of 10 g mL 1 of Mn 3 O 4 ) for additional 12 h

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Epidemiologic data has linked IGF-1R to high tumor grade and stage, and is associated with poor survival [118]

The comparison with the crystal structure of GPX4 (PDB 6HN3) revealed that a modelated GpoA display orthologous residues that could conform the catalytic site of tis enzyme, including Gln 70 , Trp 124 and Asn 125 , but Cys 36 in the place of Sec 46 (Fig