But Tirzepatide seems to edge out Wegovy slightly for emotional eaters and those with more significant amounts of weight to lose
When considering how does tirzepatide work, you'll find that it supports weight loss by slowing digestion and promoting a feeling of fullness, resulting in an average weight reduction of 15% to 20% over 72 weeks
Fatigue is one of the most common things people ask about when they begin GLP-1 medications, especially in those first few weeks when everything feels new
Undereating leads to muscle loss, nutrient deficiency, and metabolic slowdown
Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity
Sources Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial (2024) Journal of the American Medical Association [Accessed 2 December 2025] Dosing Schedule | Ozempic (semaglutide) (2025) [Accessed 2 December 2025] GIP and GLP1, the two incretin hormones: Similarities and differences (2010) Journal of Diabetes Investigation [Accessed 2 December 2025] Once-Weekly Semaglutide in Adults with Overweight or Obesity (2021) New England Journal of Medicine [Accessed 2 December 2025]