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Yes, with precautions

Patients face safety risks with counterfeit and compounded prescription weight-loss drugs Officials warn of counterfeit and compounding pharmacy concerns as demand for weight-loss medicines surges

It works upstream

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5.2 Limitations of conventional topical flavonoid delivery Although certain flavonoids such as naringenin and flavanone exhibit enhanced skin permeability under inflamed or barrier-compromised conditions, their transdermal absorption remains limited in intact skin, often necessitating the use of penetration enhancers to achieve therapeutic depth (Wang et al., 2024)