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Although NQO1 is not as studied in the field of MASLD, the studies that have been conducted to date have shown varying results regarding the expression and/or activity of this enzyme in MASLD/MASH patients as well as in many MASLD/MASH animal or cell models (Table S6)

High-fat diet decreases tyrosine hydroxylase mRNA expression irrespective of obesity susceptibility in mice

Myc or NMyc increase gene expression in glioblastoma, including those involved in glycolytic flux, and reduces the NAD + pool, leading to increased glioma cell sensitivity to NAMP inhibition

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Meissner, W

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