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[DOI] [PubMed] [Google Scholar] 4.Khavinson V.K., Bondarev I.E., Butyugov A.A

Together, these findings demonstrate that, in contrast with acute exposure, chronic disruption of iron homeostasis with consequent GSH depletion remodels cellular redox homeostasis over time, inducing a state we term chronoferroptosis: a persistent ferroptotic adaptation characterized by coordinated alterations in iron-handling and antioxidant defense proteins that may represent early vulnerability to neurodegenerative pathology

For instance, you might be coming off a stimulant drug and experience anhedonia while the drugs leave your system

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Willard, F.S., et al