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According to the working model, these cysteine residues may undergo chemical modification/remodeling including trisulfide bond formation and/or related reactions, resulting in a regional (minor, but effective) structural alteration that enhances c-met binding and the nitration resistance of Y198-HGF

Some exceptions may apply to different regions

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Chronic illness and long term toxin exposure may deplete stored glutathione as well as hinder its production

American College of Medical Toxicology position statement on post-chelator challenge urinary metal testing

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