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Direct hepatic effects

In the SURPASS-1 trial, which included 478 patients with obesity and type 2 diabetes, Tirzepatide significantly reduced body weight by 11.3% after 52 weeks, compared to 2.4% with placebo

Liraglutide uses a shorter C16 fatty-acid chain attached by a single glutamate spacer, while semaglutide uses a longer C18 diacid with a bifunctional gamma-glutamate and mini-PEG linker

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[ [112] Peng W, Zhou R, Sun ZF, Long JW, Gong YQ

These findings highlight the increasing prevalence of GLP-1 RA use since 2020 and its significant impact on health care expenditures in diabetes care in the United States