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For GHK-Cu, where the cosmetic mechanism depends on copper ion delivery to fibroblast integrins that trigger TGF- signaling and collagen gene expression, that localized dermal concentration is the only variable that matters

The pooled effect size was homogenous ( I 2 = 0%) (Fig

quantification of proteins was carried out with the BCA reagent

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In some organs, such as the heart and brain, acute inflammation can be fatal