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Interestingly, in a pilot study, exposure of autologous glioma cells treated ex vivo with IGF-1R antisense oligos induced partial tumour regression in some patients with malignant astrocytoma (Andrews et al, 2001)

In one series, approximately 50% of patients experienced a local recurrence after primary excision of DM, usually within 3 years of excision

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Fradkins input into this consensus report is from her own perspective and the Report does not reflect the view of the National Institutes of Health, Department of Health and Human Services or the US Government