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1,4 To minimize the need for confirmatory testing, consider using morphine or codeine in high-risk patients

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Although the etiology of depression has not been fully elucidated, current scientific data emphasize the role of neurotrophic factors deficiencies, disturbed homeostasis between the nervous system and the immune and endocrine systems, as well as disturbances in brain energy metabolism and dysfunctions in the gut-brain axis as important factors in the pathogenesis of this neuropsychiatric disorder

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Mass spectrometry ESIMS experiments were performed on a quadrupole time-of-flight (qTOF) Bruker Maxis Impact mass spectrometer (Bruker Daltonik GmbH) calibrated with a commercial ESI-TOF tuning mix (Sigma-Aldrich)

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