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It's like paying to fully renovate a house you only rent until 2033

Increasing the dose might work but adds risk

Referenced Citations Ng FM, et al

Recent Findings Several unimolecular dual-receptor agonists have shown promising clinical efficacy studies when used alone or in conjunction with approved glucose-lowering medications

In some cases, they couldn't find any published clinical studies in humans and there were safety concerns like the potential to encourage cancer growth or to trigger a massive immune response