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Remarkably, ~5090% reduction of L68Q-hCC staining was observed in five of the treated carriers suggesting that L68Q-hCC is a clinical target for reducing agents

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Administration of CBP or LDH inhibitors, or cell-penetrating peptides that can specifically block the lactylation of MRE11, can reduce the lactylation of MRE11, inhibit HR, and enhance the sensitivity of tumor cells to chemotherapeutic agents such as cisplatin, PARPi, etc [26]

Clin Ophthalmol Auckl NZ

Notably, administration of Fer-1 or overexpression of SIRT7 effectively alleviated Ang II-induced epithelial-mesenchymal transition (EMT) and renal ferroptosis in hypertensive mice by suppressing the KIM-1/NOX4 signaling pathway and activating the KLF15/NRF2 and xCT/GPX4 signaling pathways, respectively [263]

Ecotoxicol Environ Saf 173:273284 Velikova V, Yordanov I, Edreva A (2000) Oxidative stress and some antioxidant systems in acid rain-treated bean plants