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Microbial-derived metabolites, including but not limited to SCFAs, exert distal immunomodulatory effects through systemic circulation and vagus nerve signalingnotably regulating Treg cell differentiation and suppressing neutrophilic infiltration in bronchial tissues via G protein-coupled receptor (GPCR) signaling pathways ( 2 Methods 2.1 Search strategy To identify published studies, we conducted a comprehensive search of PubMed and Embase databases, covering records up to January 2025

Akram M, Hafeez A, Sabir S, Din Khan IU

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Y., Segal, D., Qian, W

Nature 489:519525 Cancer Genome Atlas Research Network (2014) Comprehensive molecular profiling of lung adenocarcinoma