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Notably, studies have reported that DSIP-mediated analgesia occurs without the tolerance development typically seen with exogenous opioid compounds, suggesting a fundamentally different mechanism of interaction with the opioid system

All versions include bupropion HCl, an aminoketone antidepressant that may help curb appetite and food cravings via norepinephrine and dopamine pathways

Neuron 108 , 691706.e610 (2020)

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The necrotic nucleus extends outward into a region with low oxygen concentrations, referred to as hypoxia