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AOD-9604 progressed through six human clinical trials with more than 900 participants but failed to reach statistical significance in its Phase IIb obesity endpoint, and Metabolic Pharmaceuticals terminated development in 2007

Although these proteins were present for 23 hours longer in the plasma than the original GLP-1, they resulted in fluctuation of blood levels with once-daily or twice-daily administration [17]

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doi:10.1002/cpt1972133426