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Its Phase 2 obesity trial published in Lancet Diabetes & Endocrinology (2024) showed up to 18.7% weight loss at 46 weeks, while a separate Phase 2 MASH trial demonstrated significant MASH resolution, earning FDA Breakthrough Therapy Designation

This mechanism is independent of food intake and appears to be, in part, mediated by the sympathetic nervous system and the -2 adrenoreceptors expressed in white adipose tissue [109]

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