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The primary outcome was the mean percent change in BMI from randomization to 1 year

Because GLP-1 medications reduce appetite, it can be easy to under-eat protein, which may lead to muscle loss

Effects on pain signaling and inflammation are currently based on animal models

Nature 2008;454:42835

Although precise hepatic anti-inflammatory mechanisms remain incompletely defined, proposed pathways include reduction of lipotoxicity-induced cellular stress, modulation of hepatic macrophage activity, and direct effects on inflammatory signaling cascades [26]