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It is noteworthy that the temporal sequence of anti-inflammatory effects and the changes in troponin were similar, and these were delayed compared with effects on circulatory volume and pressure, further supporting a distinct mechanism

The choice between direct and indirect approaches fundamentally reshapes study design, outcome measurements, and interpretability of results

doi: 10.3389/fphys.2016.00206 136 BinionDGRafieePRamanujamKSFuSFisherPJRiveraMTet al

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