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In the PIONEER 6 trial, hypoglycemia was reported in 1.4% of patients using oral semaglutide compared to 0.8% in the placebo group

Some practitioners use a strategy of reaching target weight with full-dose GLP-1, then gradually reducing to a GLP-1 maintenance dose while continuing HRT

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The study found no significant difference in overall efficacy between the two drugs at optimized doses [3]