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But here are the patterns that have emerged from thousands of GLP-1 protocols: Injecting on a mostly empty stomach Some people find that injecting two to three hours after a light meal, when the stomach is mostly empty but not completely vacant, produces the least nausea

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Individuals who may need to avoid or use retatrutide with caution include: Those with severe gastroparesis or other severe gastrointestinal conditions that could be worsened by delayed gastric emptying this is a recognised caution for the class in UK SmPCs People with a history of pancreatitis , given the unconfirmed but precautionary signal associated with GLP-1-based therapies Those with a history of gallbladder disease or gallstones , given the class-associated risk of cholelithiasis and cholecystitis Those who are pregnant or breastfeeding , as safety data in these populations is entirely absent