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Impairment in the regulation of the IGF axis plays a significant role in both the proliferation of cells and the inhibition of apoptosis

In one pooled analysis, the risk of suicidal ideation in patients treated with atomoxetine was 5/1,357 patients vs

Given the conserved role of this pathway on lifespan, therapeutic strategies, such as insulin-like growth factor-1 receptor (IGF-1R) monoclonal antibodies (mAb), represent a promising translational tool to target human aging

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However, high development costs and lengthy approval times pose scalability challenges

This is a meaningful practical benefit that most patients do not think to use when first enrolling