Annual review of nutrition 34, 237260, doi: 10.1146/annurev-nutr-071812-161201 (2014)
The Journal of Headache and Pain, 23(1), 34
One of the MDLs is centered on gastrointestinal injuries associated with these drugs, while the other, smaller MDL is focused on NAION and vision loss
Results first, gas chromatography/mass spectrometry (GC/MS)-based untargeted metabolomics revealed that bTNF- altered the metabolism of bFLS, increasing glucose, isoleucine, leucine, methionine, valine, tyrosine, and lysine and decreasing malate, fumarate, -ketoglutarate, stearate, palmitate, laurate, aspartate, and alanine
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No direct adverse effects on male fertility was observed at doses up to 1 mg/kg/day, a high dose yielding an estimated systemic exposure 11-times the exposure in obese humans at the MRHD, based on plasma AUC comparison