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The biological significance of substrate inhibition: a mechanism with diverse functions

202 In early assessments of autism, the amygdala exhibits reduced volume and increased neuronal density in the medial, central and lateral nuclei, which play critical roles in modulating fear conditioning, anxiety and social behaviour

Here, we present ProTox-II that incorporates molecular similarity, pharmacophores, fragment propensities and machine-learning models for the prediction of various toxicity endpoints

Five years later, GSK shuttered the Sirtris program without successful drug development

The superfamily of cytosolic sulfotransferases is subsequently divided into families and subfamilies according to the amino acid sequence identity among individual SULTs