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Mood and Energy Boost Some individuals report improved mood and energy levels while using GLP-1 medications

Activation of GLP-1R also enhances the levels of anti-inflammatory cytokines like IL-4 and IL-10, along with increasing the expression of the neuroprotective factor -endorphin in microglia [112]

Hooked up to IV bags, half of which contained GLP-1 and the other half just saline, the men were then encouraged to eat from a buffet lunch until they were comfortably satisfied

"GLP-1 medications are truly a breakthrough in weight management, but they can also create significant nutrient gaps in things like vitamin B12, vitamin D, iron and calcium," says Matthew Taylor, Sr

Numerous practice guidelines recommend multicomponent, evidence-based nutritional and behavioral therapy for adults with obesity, but use of such therapies with GLP-1s is not widespread

At the same time, the visible nature of weight loss can reinforce adherence, at least in the early stages