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[13] In a newly diagnosed vitamin B 12 -deficient patient, normally defined as when serum levels are less than 200 pg/ml, daily IM injections of hydroxocobalamin up to 1,000 g (1 mg) per day are given to replenish the body's depleted cobalamin stores

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333,334 However, in patients with T2DM, correcting hyperglycemia with insulin therapy has a limited impact on DPN