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"Lipoic acid reduces the activities of biotin-dependent carboxylases in rat liver." J Nutr

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In particular, this latter product has been identified in cells treated with busulfan and is a chemically stable structural analogue of glutathione disulfide, of which it does not have the reducible disulfide bond but retains the structural motifs for recognition by the glutathione disulfide-binding site of the enzyme

Loss in body weight is an independent prognostic factor for mortality in chronic heart failure: Insights from the GISSI-HF and val-HeFT trials