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Network pharmacology analysis suggested that the KEAP1-NRF2 pathway might be involved in the protective effects of SFN on psoriasis

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The carriers of CYP3A5 rs776746 A allele were overrepresented in the intentionally overdosed group and were more predisposed to acetaminophen-induced hepatotoxicity than individuals with the G allele, that rendered CYP3A5 enzyme inactive due to aberrant gene splicing [100]

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10.1038/s42255-020-00305-3 15 Deryabin PavelI.Shatrova AllaN.Borodkina AleksandraV

Method validation Sample preparation efficiency Extraction recovery, matrix effects, acid effects, and deproteinization efficiency were evaluated for the three extraction solvents mentioned above, including MPA, SSA, and TFA