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286 Besides, -catenin responsive transcription (CRT) is another crucial therapeutic target in combating various cancers and CRT-inhibitory drugs (iCRT3, iCRT5, iCRT14) are specifically cytotoxic to human colon cancer cells and enhance the infiltration of T and NK cells in syngeneic mouse models of CRC by blocking -catenin/TCF interaction

doi: 10.1017/S0954422410000247

CJC-1295 enhances GH pulse amplitude, while Ipamorelin increases pulse frequency, enabling investigation of synergistic GH/IGF-1 responses

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Furthermore, the combination of CB-839 and 5-fluorouracil (5-FU) has been shown to induce regression in tumors with PIK3CA mutations

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