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doi:10.1186/s12937-016-0207-4

Similarly, the sample size in the TRIUMPH1 knee OA basket is designed to provide at least 90% power to detect a clinically meaningful benefit of retatrutide 9 and 12 mg versus placebo in the change in WOMAC pain subscale score, assuming each dose is analysed separately in parallel using a Satterthwaite t test at a 2sided significance level of 0.0125, accounting for differences that have been observed historically in variability between placebo and active arms

doi:10.3109/00016489309126206 Chu CH, Liu CJ, Lin LY, Chen TJ, Wang SJ

Barnes and K

Clinical trial data published in the New England Journal of Medicine found that tirzepatide produced meaningfully greater weight loss than semaglutide on average in patients with obesity