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When combined with medications that alter fluid balance and appetite regulation, these risks deserve heightened attention

Patients with a history of gastroparesis, severe gastrointestinal disease, or inflammatory bowel disease require careful evaluation, as delayed gastric emptying induced by semaglutide may potentially worsen symptoms or interfere with the absorption of other medications

The medication undergoes proteolytic degradation with minimal renal clearance, with a half-life of approximately five days, allowing for convenient weekly dosing

Starting with a low dose and gradually increasing it can help reduce this side effect

How can the new drugs help

Make protein your non-negotiable