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As future doctors, we are taught to always warn patients on sulfonylureas about hypoglycemia symptoms shakiness, sweating, confusion and to always carry sugar with them. Mohammad Junaid Rain, MBBS 2nd Year Key advantages of Sulfonylureas: Very affordable 30100/month in India Available everywhere even in small town pharmacies Strong blood sugar lowering effect Decades of safety data Key disadvantages: Hypoglycemia risk can cause dangerous low blood sugar Weight gain 24 kg on average Beta cell burnout with long term use, pancreas gets more exhausted Not ideal for elderly patients or those who skip meals Hypoglycemia warning signs to tell your patients: What to do: Immediately eat 23 teaspoons of sugar or drink a glass of fruit juice