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Tirzepatide, the active ingredient in Mounjaro and Zepbound, is a 39-amino acid dual agonist targeting both GLP-1 and GIP receptors, also incorporating a fatty acid modification for half-life extension, and is the most commercially significant synthetic peptide ever produced at scale

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[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Hansotia T, et al

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The solute carrier family 5 member 8 (SLC5A8) is considered the primary butyrate transporter across the apical membrane of the colonocytes ( Butyrate and liver metabolism The liver is the master organ for regulating energy homeostasis, particularly for lipid and glucose metabolism regulation