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Coskuns research contributions span the entire development arc of GLP3: Discovery and initial characterization of GLP3s triple-receptor agonist properties and pharmacological profile Preclinical studies establishing proof-of-mechanism in mouse models and in vitro receptor systems Design and medical oversight of phase 1b and phase 2 clinical trials in type 2 diabetes and obesity Investigation of GLP3s effects on gastric emptying and mechanistic studies of weight loss Contribution to over 168 peer-reviewed publications in metabolic disease research with citation impact exceeding 8,700 citations His work extends beyond GLP3 to include fundamental contributions to the development of GLP2 and advancement of incretin-based therapeutics more broadly
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While phentermine is a good fit for some (its often Jennifers starting point for younger patients due to its efficacy and cost), Daniell felt that taking the medication multiple times per day would be challenging
As with other experimental peptides, the risks of black-market sourcing and unsupervised use outweigh potential short-term benefits
