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Permanent treatment discontinuations because of AEs were more common with liraglutide (12.6% [n = 16]) vs semaglutide (3.2% [n = 4]) and placebo (3.5% [n = 3])
Use With Caution in Research Contexts Because Retatrutide interacts with GLP-1, GIP, and glucagon receptor pathways involved in metabolism, appetite regulation, gastric-emptying pathways, and glucose signaling, additional caution may be warranted in research models involving significant metabolic, gastrointestinal, pancreatic, or cardiometabolic conditions
Among the differential metabolites, the top 10 VIP metabolites are selected for correlation analysis
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In addition, the results of these trials primarily focus on secondary prevention and exhibit enhanced advantages in patient cohorts with markedly elevated Lp(a) levels
