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But the more overweight you are, the more difficult it is to exercise, right

[DOI] [PubMed] [Google Scholar] 94.Davies MJ, van der Meer P, Verma S, Patel S, Chinnakondepalli KM, Borlaug BA, et al

Surgery isnt considered a cure for lipedema, but it can help reduce pain in the affected limbs, improve mobility, and prevent complications

Modulation of incretin and neuroendocrine signaling, including glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, amylin, and glucagon pathways

Then you have some drugs that have neuropathy as a side effect