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For example, all participants in EMPA-REG OUTCOME had established atherosclerotic CVD, compared with approximately 65% of participants in CANVAS, 50% in CREDENCE, and approximately 40% in DECLARE TIMI-58

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State Medicaid programs and manufacturers were requested to submit their intentions to participate by January 8, 2026, and the model is expected to begin in May 2026

The analyses were conducted on the above cohorts: (1) SGLT2i and (2) GLP-1 RA with each analysis propensity score matched (PSM) for age, sex, BMI, presence of heart failure (ICD-10-CM-I50), hypertension (ICD-10-CM-I10), ischaemic heart disease (IHD) (ICD-10-CM-I2025), chronic kidney disease (CKD) (ICD-10-CM-N18) and HbA 1c value so as to balance the analysis (1:1 matching) being undertaken

But the regulatory difference is real and should be part of your informed consent conversation with your provider - not something you discover after your first shipment arrives

American Society of Clinical Oncology (ASCO) Annual Meeting 2025