The consideration of cysteine during these simulations were important, as cytosolic cysteine is the rate limiting amino acid precursor for synthesis of GSH, via the -glutamylcysteine synthetase (GCS) enzyme, and this is a function of its reduced concentration compared to the other precursors, glycine and glutamate
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It was FDA-approved in 2010 as a weight loss medication for Netherlands HIV patients suffering from lipodystrophy, a condition that leads to an accumulation of fat (adipose tissue) in the abdominal area
Accuracy of quantification was below 6% for all quantified metabolites except glutamic acid (13.9%)
Jorsal A, Kistorp C, Holmager P, Tougaard RS, Nielsen R, Hnselmann A, et al
Low vitamin B12 levels are associated with having increased levels of homocysteine, contributing to higher levels of depression [2,3]