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J Neurol Neurosurg Psychiatry 1982

As a result of the study, it was observed that the administered melatonin had a beneficial effect on the lipid profile, the percentage of fat present in the abdominal cavity, the body weight of the rats, and also the overall insulin concentration in the body

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10.1016/j.cell.2013.12.010 137 YangN.JiaK.DaiK.WuQ.YanH.TongH.et al (2025)

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For renal impairment, although most GLP-1 agents have minimal renal clearance, impaired kidney function increases the risk of adverse events such as dehydration from vomiting or decreased drug clearance in polypharmacy