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Other studies back this up, showing that long-term exposure reduces the drug's effects [25]

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Konturek SJ, Brzozowski T, Konturek PC, et al

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Moreover, activated Nrf2 can also dock on the AREs in Mfn2 gene promoter to promote mitochondrial fusion (Hu et al., 2021)

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This is a 6.75 fold increased in percent weight loss from highest dose to placebo, compared to the 5.9 fold increase seen in the STEP-1 trial

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Global, regional and national burden of rheumatoid arthritis 19902017: a systematic analysis of the Global Burden of Disease study 2017

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