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7 Tirzepatide is a unimolecular, bifunctional peptide invented by Eli Lilly and Company (Indianapolis, IN, USA), which simultaneously activates GLP-1R and GIPR

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The distribution of potential effect modifiers (HbA 1c and body weight at baseline) was deemed sufficiently similar across all treatment comparisons to assume that a network meta-analysis was appropriate (ESM Figs 2 and 3)

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