Cyanocobalamin is added as nutritional support, as B12 deficiency risk may increase with GLP-1-mediated dietary restriction and reduced intrinsic factor-dependent absorption
doi:10.1016/S0140-6736(21)00845-X
Volume 44)
A report from the Framingham Offspring Study of 2,999 adults found the following average daily B12 intakes, including fortified foods and supplements (Tucker, 2000): Age 26-49: 8.9 g Age 50-64: 8.7 g Age 65-83: 8.5 g A 2015-2016 National Health and Nutrition Examination Survey of over 4,500 adults 60 years and older found the following average daily B12 intakes (USDA NHANES, 2019): Male non-supplement users (68% of men): 4.5 g Male supplement users: 5.3 g from food plus 326 g from supplements Female non-supplement users (63% of women): 3.6 g Female supplement users: 3.8 g from food plus 520 g from supplements European Food Safety Authoritys Recommendations In 2015, the EFSA released recommendations for B12 intake across Europe
For perspective, that level of efficacy means someone weighing 220 pounds could expect to lose approximately 53 pounds over 48 weeks
Certain health conditions that affect the gut, like Crohns or celiac disease, can also make absorption a major challenge