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Extrapituitary expression of GH has been detected in the human retina and vitreous fluid, 94 and GH has been demonstrated to directly stimulate the proliferation of human retinal microvascular endothelial cells in vitro

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Together, these findings suggest that molecular signatures of treatment responsiveness exist, although their translation into consistent and clinically applicable predictive frameworks remains limited 41

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Anal Lett 54(14):22762292