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3 (download XLSX Numerical data for spectra at varying GSH concentrations and quantification of GSH in cells upon different treatments

Experimental data point oxidative stress as one of the factors that contributes to aquaporin-1 up-regulation since administration of the antioxidant melatonin not only reduced protein levels but also mechanical allodynia and appearance of aquaporin-1-positive fibers below laminae I and II (Nesic et al., 2008)

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Bottom line: Glutathione is a foundational molecule for cellular health

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Laboratory data showed that S-acetyl glutathione increased intracellular glutathione and had a positive effect on many oxidative stress biomarkers