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The sub-states accessible to the receptor are agonist-dependent: different ligands stabilize different subsets of this ensemble, meaning two compounds with equivalent cAMP EC values can drive the receptor into different active-state geometries that couple with different efficiencies to Gs, -arrestin, and the endocytic machinery

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WL + RT: 6.6 kg vs

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Separate and interactive regulation of cytochrome P450 3A4 by triiodothyronine, dexamethasone, and growth hormone in cultured hepatocytes