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For LC-MS analysis, samples were thawed on ice-water bath, then 40 L of whole blood was injected into 450 L cold extraction solvent comprising of mixture of Acetonitrile:Methanol:Milli-Q water in ratio 40:40:20 according to protocol described in Presterud et al 35

Pannasch, U

The actual reason no generic exists yet is that no manufacturer has filed an Abbreviated New Drug Submission (ANDS) referencing Wegovy specifically demonstrating bioequivalence at the higher Wegovy doses and pursuing the weight-management indication is a separate regulatory exercise from the diabetes-indication ANDS filings that have just cleared

Withdraw the needle carefully and apply gentle pressure to the injection site with a clean tissue if needed

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