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Chronic pain often stems from inflammation and oxidative damage to tissues

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HPN-07 scavenges free radicals, inhibits iNOS, COX-2 and NF-B, and reduces excitotoxicity 28,29

What we know so far: Coverage is forming - Foundayo was FDA approved April 1, 2026 Plan type matters - Large employers may have more flexibility Self-pay is affordable - $149-$349/month via LillyDirect (vs $1,000+ for injectable GLP-1s) Why this is good news Even without insurance coverage, Foundayo is one of the most affordable GLP-1 options available

Pfizer terminated lotiglipron in October 2023 due to dose-dependent liver enzyme elevations, and subsequently discontinued danuglipron in April 2025 after a single case of potential drug-induced liver injury was identified in a dose-optimization study