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Shah AB, et al

doi: 10.1038/s41580-020-00324-8 130 RatliffBBAbdulmahdiWPawarRWolinMS

The body maintains uric acid balance through production and excretion, primarily via the kidneys

That said, mild effects can occur in some people, especially when starting any new supplement: Temporary bloating or fullness (more common with collagen) Mild digestive discomfort if taken without enough water These are usually short-lived and can be reduced by: Taking supplements with adequate water Starting with recommended doses Choosing high-quality, well-absorbed formulations Using clinically formulated products from trusted brands helps minimize unnecessary reactions

Papadavid E, Rompoti N, Theodoropoulos K, Kokkalis G, Rigopoulos D (2018) Real-world data on the efficacy and safety of apremilast in patients with moderate-to-severe plaque psoriasis

Here, we focus on the major tasks of the diverse taste cells rather than describing detailed signaling mechanisms which have been recently reviewed elsewhere [15]