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However, such a benefit might not be seen with DPP-4 inhibitors, since these drugs primarily potentiate levels of GLP-1 in the gastrointestinal tract and have modest effects on GLP-1 receptors in the systemic circulation [4]
Severe or persistent myalgia is uncommon and warrants clinical evaluation to rule out other underlying conditions or complications
Rodier, Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence
Furthermore, the majority of studies presented herein is fairly acute and carried out in mice without obesity or diabetes, limiting generalization of the findings to these important metabolic comorbidities