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In recent years, studies have emerged that have identified brain insulin resistance and impaired insulin signaling as key pathogenetic factors underlying cognitive impairment

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( Statements Author contributions J-YW and Q-WW wrote the first draft of the manuscript

doi: 10.1186/s13195-021-00813-8 33 Tahami MonfaredAATafazzoliAYeWChavanAZhangQ

For this population-based study, researchers used medical records from about 45 million people in the United States listed in the TriNetX real-time federated health research network who all had at least one outpatient or inpatient doctor visit between 2011 and 2023